How LLINs Work to Reduce Malaria
Communities with high malaria transmission and pyrethroid resistance have a new pioneering tool to fight insecticide resistance: PermaNet® 3.0, the first PBO LLIN on the market and the first recommended by the WHO.
Backed by ten years of rigorous research, a unique design and an obsessive drive to fight insecticide resistance with a superior product, PermaNet® 3.0 meets the National Malaria Country Programs' demand for an innovative tool to address the alarming increase of mosquitoes with pyrethroid resistance.
PermaNet® 3.0 offers a unique construction marked by its distinctive blue roof and an effective, new formulation. Utilizing a combination of a pyrethroid insecticide and piperonyl butoxide (PBO), PermaNet® 3.0 increases the efficacy of pyrethroids by blocking the metabolic enzymes that the mosquito uses to break down the insecticide. It offers the highest level of user comfort, made from the softest, most breathable polyester mesh, thus increasing the likelihood of utilization. Since mosquito behavioral studies show that mosquitoes first contact the LLIN on the roof, PermaNet® 3.0 is designed with a polyethylene roof panel incorporated with deltamethrin and PBO to target mosquitoes with metabolic resistance.
PermaNet® 3.0 is registered across most malaria endemic countries and is an early market leader with the most deployed PBO nets.
The WHO reports widespread pyrethroid resistance. In the 2017 World Malaria Report, 81% of malaria endemic countries now report resistance to pyrethroids.
Change in estimated malaria cases (2015 vs 2016) and reports of confirmed pyrethroid resistance in Anopheles mosquitoes. Data sources: World Malaria Report 2017 and IR Mapper (www.irmapper.com).
Vestergaard was the first to respond to the need for a new tool to fight insecticide resistance. In addition to the development of PermaNet® 3.0, Vestergaard conceived IR Mapper (www.irmapper.com), an online platform that tracks insecticide resistance across malaria endemic countries. Vestergaard is an active partner with local governments, including a public-private partnership between Vestergaard and Noguchi Memorial Institute for Medical Research in Accra, Ghana with a primary goal to strengthen research and development of vector control tools and provide opportunities for knowledge sharing, capacity building and collaboration.
PermaNet® has among the largest installed production capacities in the industry, which have been scaled-up and enhanced over the last 10 years for consistent quality.
PermaNet® 3.0 is designed to last at least 20 WHO standard washes and 3 years of field use. However, the lifetime largely depends on usage and local field conditions. Vestergaard does not stand liable for differences in the lifetime of PermaNet® 3.0 regarding field use, the differences arising primarily due to potentially harsh washing conditions, exposure to UV rays, soiling, etc., under field conditions.